Static Physician Global Assessment of Genitalia (sPGA-G)

DESCRIPTION:
The Static Physician Global Assessment of Genitalia (sPGA-G) scale is a 6-point measure used to evaluate the severity of genital psoriasis. The score ranges from 0 (clear) to 5 (very severe). The assessment is considered "static" because it refers to the subject's disease state at the time of the assessment, without comparison to any of the subject's previous disease states, whether at baseline or at a previous visit.¹

DISEASE STATES: 
Psoriasis

VALIDATED USES: 
Treatment monitoring in clinical trials/research in conjunction with PASI, guiding treatment decisions in clinical practice

ADMINISTRATION METHOD:
Physician, clinician, HCP representative

COMMONLY USED IN:
Clinical trials, research, clinical practice

DETAILED DESCRIPTION:
Based on the Physician Global Assessment (PGA), the 6-point sPGA-G involves a visual evaluation of the skin by a physician, clinician, or an appropriate HCP representative who then assigns a score to the patient’s genital psoriatic lesions. The psoriatic lesions are graded for erythema (e), induration (i), and scaling (s) based on a scale that ranges from 0 to 4.^1,2

The final sPGA-G is a composite score that is generated from an average of the 3 domain scores (final sPGA-G score = e+i+s/3). A lower average score indicates less severity, with 0 being clear and 1 being almost clear.^1,2

sPGA-G RATING SCALE^1,2

Note: Clear requires a “0” for all 3 domains (e, i, s). The total score average is rounded to nearest whole number score; e.g., if the total is ≤2.49, the score is 2; if the total is ≥2.50, score is 3.

VALIDITY:
Merola et al. 2017 demonstrated that the sPGA-G is a reliable measure for determining the severity of genital psoriasis and demonstrated high interrater reliability using Kendall’s coefficient of concordance with values ranging from 0.678 to 0.856.¹

LIMITATIONS:
The sPGA-G is only designed to evaluate psoriasis affecting the genitalia. It is not designed to assess adjacent body regions or secondary features of genital psoriasis such as erosion, fissures, and secondary candidiasis. In clinical practice, HCPs need to consider the impact of additional features and body sites when treating patients with genital psoriasis.¹

This resource is intended for educational purposes only and is intended for US healthcare professionals. Healthcare professionals should use independent medical judgment. All decisions regarding patient care must be handled by a healthcare professional and be made based on the unique needs of each patient.

References: 1. Merola JF, Bleakman AP, Gottlieb AB, et al. The Static Physician's Global Assessment of Genitalia: a clinical outcome measure for the severity of genital psoriasis. J Drugs Dermatol. 2017;16(8):793-799. 2. Cappelleri JC, Bushmakin AG, Harness J, Mamolo C. Psychometric validation of the physician global assessment scale for assessing severity of psoriasis disease activity. Qual Life Res. 2013;22(9):2489-2499. doi:10.1007/s11136-013-0384-y